Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus
نویسندگان
چکیده
منابع مشابه
The parafascicular thalamic nucleus concomitantly influences behavioral flexibility and dorsomedial striatal acetylcholine output in rats.
Recent evidence suggests that a circuit involving the centromedian-parafascicular (Pf) thalamus and basal ganglia is critical for a shift away from biased actions. In particular, excitatory input from the Pf onto striatal cholinergic neurons may facilitate behavioral flexibility. Accumulating evidence indicates that an endogenous increase in dorsomedial striatal acetylcholine (ACh) output enhan...
متن کاملDifferential processing of thalamic information via distinct striatal interneuron circuits
Recent discoveries of striatal GABAergic interneurons require a new conceptualization of the organization of intrastriatal circuitry and their cortical and thalamic inputs. We investigated thalamic inputs to the two populations of striatal neuropeptide Y (NPY) interneurons, plateau low threshold spike (PLTS) and NPY-neurogliaform (NGF) cells. Optogenetic activation of parafascicular inputs evok...
متن کاملTwo distinct populations of projection neurons in the rat lateral parafascicular thalamic nucleus and their cholinergic responsiveness.
The lateral parafascicular nucleus (lPf) is a member of the intralaminar thalamic nuclei, a collection of nuclei that characteristically provides widespread projections to the neocortex and basal ganglia and is associated with arousal, sensory, and motor functions. Recently, lPf neurons have been shown to possess different characteristics than other cortical-projecting thalamic relay neurons. W...
متن کاملRole of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats
The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. Acute corneal nociception was ind...
متن کاملNeurobiology of Disease Involvement of the Thalamic Parafascicular Nucleus in Mesial Temporal Lobe Epilepsy
Mélanie Langlois,1 Pierre-Olivier Polack,3 Hélène Bernard,1 Olivier David,2 Stéphane Charpier,3 Antoine Depaulis,1 and Colin Deransart1 1Equipe 9, Dynamique des Réseaux Synchrones Epileptiques, and 2Equipe 5, Neuroimagerie Fonctionnelle et Métabolique, Grenoble Institut des Neurosciences, Institut National de la Santé et de la Recherche Médicale U 836-Université Joseph Fourier-Commisariat à l’E...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2019
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2019.02.035